From time to time Eurolines offer regular coach services between the UK and Luxembourg, departing Victoria Coach station at 10 am on Mondays, Wednesdays and Fridays, and arriving at 23:30 in Luxembourg City (with a 2 hr stopover [/bus change] in Brussels). The cost of the tickets varies but starts at £44 one-way and £77 return, and seems to be among the cheapest ways to get to Luxembourg from the UK.

Please note that while this info is correct at the time of writing (cf below), this service has in the past been withdrawn and re-instated a number of times, so please check with Eurolines if the service does indeed operate and/or if its timetable may have changed.

Just in case the Eurolines timetable was of no use to you, it's worth bearing in mind that there are a number of Coach tours to Luxembourg, by which we mean a tour by coach that starts in the UK, takes you to Luxembourg and caters for you while there (Hotel + excursions + meals + activities, etc) from 2 days to a week or more and then returns to the UK. These are listed on our page of UK Tour Operators featuring Luxembourg